Home Neoplasma 2018 Neoplasma Vol.65, No.6, p.865-871, 2018

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

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Neoplasma Vol.65, No.6, p.865-871, 2018

Title: Aclidinium bromide inhibits human glioma cell proliferation, migration and invasion and promotes apoptosis via the PI3K/AKT signaling pathway
Author: S.H. HUANG, T. ZHANG, C.G. ZHAO, J. QIN, P. QI, F.T. LI, X.J. HE

Abstract: This study investigates the anti-cancer potential of Aclidinium bromide (INN) in glioblastoma. Glioblastoma cell lines U251 and U87 were treated with INN and its effects on cell migration and invasion were assessed by transwell migration and invasion assays. The effects of INN on proliferation and apoptosis were detected by CCK-8 kit and flow cytometry, and Western blotting determined anti-apoptotic proteins and signaling pathway changes. The results show that INN effectively suppressed proliferation, migration and invasion and induced apoptosis in U251 and U87 cells, respectively. Furthermore, the expression levels of the Bcl-2 anti-apoptotic protein was significantly decreased while Bax and caspase-3 expression were both increased in glioblastoma cells (all, p

Keywords: aclidinium bromide, glioblastoma, proliferation, migration, invasion, apoptosis
Published online: 18-Jun-2018
Year: 2018, Volume: 65, Issue: 6 Page From: 865, Page To: 871

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