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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

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neo_2018_171117N705

Title: Aclidinium bromide inhibits human glioma cell proliferation, migration and invasion and promotes apoptosis via the PI3K/AKT signaling pathway
Author: S.H. HUANG, T. ZHANG, C.G. ZHAO, J. QIN, P. QI, F.T. LI, X.J. HE

Abstract: The aim of the study was to investigate the anticancer potential of Aclidinium bromide (INN) in glioblastoma. Glioblastoma cell lines U251 and U87 were treated with INN. The effects of INN on cell migration and invasion were assessed by transwell migration and invasion assays. Additionally, the effects of INN on the proliferation and apoptosis were detected by CCK-8 kit and flow cytometry. Western blotting was employed to determine anti-apoptotic proteins and the signaling pathway changes. The results showed that INN effectively suppressed proliferation, migration and invasion and induced apoptosis in U251 and U87 cells, respectively. Furthermore, the expression levels of antiapoptotic proteins Bcl-2 was significantly decreased whereas the expression of Bax and caspase-3 were increased in glioblastoma cells (all, P

Keywords: Aclidinium bromide, glioblastoma, proliferation, migration, invasion, apoptosis
Published online: 18-Jun-2018
Year: , Volume: , Issue: Page From: , Page To:
doi:10.4149/neo_2018_171117N705


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