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ISSN 1338-4317 (online)

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Title: MicroRNA-548-3p and MicroRNA-576-5p enhance the migration and invasion of esophageal squamous cell carcinoma cells via NRIP1 downregulation
Author: X.F. NI, L.H. ZHAO, G. LI, M. HOU, M. SU, C.L. ZOU, X. DENG

Abstract: Nuclear receptor interacting protein (NRIP1), also known as RIP140, is a transcriptional coregulator that is required for the maintenance of energy homeostasis and ovulation. Although several studies have identified roles for NRIP1 in various cell processes, the biological functions of NRIP1 in esophageal squamous cell carcinoma (ESCC) remain unknown. In the present study, we demonstrate that NRIP1 inhibited the migration and invasion of ESCC cells. Further mechanistic studies revealed that NRIP1 is directly targeted by miR-548-3p and miR-576-5p. Next, we show that miR-548-3p and miR-576-5p regulated the migration and invasion of ESCC cells via inhibiting NRIP1 expression. Interestingly, in ESCC cell lines and ESCC tissues, expression of miR-548-3p and miR-576-5p was upregulated and NRIP1 was downregulated relative to the control. A statistically significant inverse association was found between the expression level of miR-548-3p/miR-576-5p and NRIP1. Taken together, our results reveal novel functions for miR-548-3p, miR-576-5p, and NRIP1 in regulating ESCC cell migration and invasion, important functions for the metastatic process in esophageal cancer.

Keywords: Esophageal squamous cell carcinoma, MicroRNA-548, MicroRNA-576-5p, NRIP1, migration and invasion
Published online: 18-Jun-2018
Year: , Volume: , Issue: Page From: , Page To:

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