Home CUSTOMERS Neoplasma 2018 Neoplasma Vol.65, No.4, p.572-578, 2018

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

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Neoplasma Vol.65, No.4, p.572-578, 2018

Title: miR-129-5p suppresses breast cancer proliferation by targeting CBX4
Author: R. MENG, J. FANG, Y. YU, L. K. HOU, J. R. CHI, A. X. CHEN, Y. ZHAO, X. C. CAO

Abstract: Deregulation of microRNA (miRNA) is closely related to cancer development and progression. Our previous study identified that miR-129-5p suppresses proliferation and metastasis in breast cancer cells. Herein, we determined that CBX4 is a miR-129-5p target gene. CBX4 is up-regulated in breast cancer tissues and while its over-expression promotes cell proliferation, its knockdown suppresses cell proliferation in breast cancer cells. Furthermore, CBX4 mediates miR-129-5p-induced inhibition of cell proliferation and negatively correlates with the expression of miR-129-5p expression. These combined results suggest that CBX4 is an oncogene in breast cancer cells, and that it may provide a novel therapeutic strategy for breast cancer treatment.

Keywords: CBX4, miR-129-5p, proliferation, breast cancer
Published online: 18-Jun-2018
Year: 2018, Volume: 65, Issue: 4 Page From: 572, Page To: 578

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