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neo_2018_180122N47

Title: The expression of clock genes cry1 and cry2 in human colorectal cancer and tumor adjacent tissues correlates differently dependent on tumor location
Author: K. HASAKOVA, M. VICIAN, R. REIS, M. ZEMAN, I. HERICHOVA

Abstract: Colorectal cancer (CRC) exhibits differences in its features depending on the location of the tumor. The role of the circadian system in the carcinogenesis is accepted and many studies report different clock gene expression in tumors compared to healthy tissue, although a little attention is given to the changes in clock genes in tumors arising from various locations across the colon and rectum. The aim of our study was to investigate the expression of the clock genes cry1 and cry2 in human CRC tissue and tissue adjacent to colorectal tumors in a cohort of 64 patients by real time PCR. Expression of cry1 was higher in tumors compared to adjacent tissues in the right-sided colon but not in the left-sided colorectum in the whole cohort of patients. Difference in cry1 expression between tumor and adjacent tissue in the right-sided colon was preserved in women and a trend was observed in men. Higher expression of cry1 in the right-sided colon tumor tissue was associated with worse survival in women. Expression of cry1 in the left-sided colorectum was significantly higher in the adjacent tissue compared to tumor in men but not in women. Expression of cry2 was lower in tumor compared to adjacent tissue in both, right and left-sided colorectum. This trend was generally preserved, but the difference reached level of significance only in left-sided colon of men. Expression of cry2 in the tumor tissue significantly correlated with location of the tumor in men with grade 2. We detected a significant correlation between tumor location and cry1 expression in the adjacent tissue. These results implicate that influence of tumor on adjacent tissue can be dependent on tumor location. Changed clock gene expression should be considered in specific subgroups of CRC patients.

Keywords: circadian, cryptochrome, grade, gender, left-sided colorectum, right-sided colon
Published online: 19-Jun-2018
Year: , Volume: , Issue: Page From: , Page To:
doi:10.4149/neo_2018_180122N47


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