Home Bratislava Medical Journal 2018 Bratislava Medical Journal Vol.119, No.6, p.385-390, 2018

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

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Bratislava Medical Journal Vol.119, No.6, p.385-390, 2018

Title: The impact of TFPI on coronary atherosclerotic burden
Author: S. Kahraman, R. Erdim, F. Helvacioglu, A. Dogan, V. Sozer, D. Gunay, S. Aytekin, V. Aytekin

Abstract: OBJECTIVES: We aimed to associate a coronary artery disease (CAD) presence and severity with endothelial dysfunction (ED), carotid intima media thickness (CIMT) and Tissue Factor Pathway Inhibitor (TFPI).
BACKGROUND: ED has a central role in atherosclerosis. CIMT and TFPI activity are also related with atherosclerosis and CAD.
METHODS: In our prospective observational study, 50 patients had CAD and 30 had normal coronary arteries. Endothelial function was evaluated by endothelium-dependent flow-mediated dilatation (FMD) and nitroglycerine-mediated dilatation (NMD) measurements. CIMT and Serum TFPI levels were also measured.
RESULTS: TFPI was a statistically significant determinant between the two groups with an increased level in CAD (+) group (84.9 ± 19.3 vs 70.2 ± 14.7, p = 0.001). There was a positive correlation between CIMT and Gensini (r = 0.34, p = 0.014). There was a strong negative correlation between Gensini and FMD-NMD, statistically significant (FMD: r = –0.715, p < 0.001; NMD: r = –0.718, p < 0.001).
CONCLUSION: We observed that ED, increased CIMT and TFPI levels were associated with CAD. Additionally, increased CIMT measurements and decreased FMD and NMD values had a positive correlation with GSS (Tab. 4, Fig. 6, Ref. 50).

Keywords: coronary artery disease, endothelial dysfunction, tissue factor pathway inhibitor
Published online: 27-Jun-2018
Year: 2018, Volume: 119, Issue: 6 Page From: 385, Page To: 390

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