Home Bratislava Medical Journal 2018 Bratislava Medical Journal Vol.119, No.7, p.401–407, 2018

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

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Bratislava Medical Journal Vol.119, No.7, p.401–407, 2018

Title: The role of proteinuria, paricalcitol and vitamin D in the development of post-transplant diabetes mellitus
Author: I. Dedinska, L. Laca, J. Miklusica, B. Palkoci, P. Skalova, D. Kantarova, P. Galajda, M. Mokan

Abstract: INTRODUCTION: Post-transplant diabetes mellitus (PTDM) occurs most frequently during the first year after transplantation. We focused on parameters of calcium-phosphate metabolism and proteinuria as possible new risk factors for PTDM after kidney transplantation.
MATERIALS AND METHODS: We have prospectively identified risk factors for post-transplant diabetes mellitus with follow-up of 12 months in a set of 167 patients after kidney transplantation. Patients with diabetes mellitus type 1 and type 2 as well as patients using ciclosporin A or mTOR inhibitor have been excluded from the monitoring. From the perspective of immunosuppression it was a homogeneous set of patients.
RESULTS: We identified the following independent risk factors for PTDM in our set: average proteinuria > 0.300 g/24 h (HR 3.0785, (95 % CI 1.6946–5.5927), p=0.0002), level of vitamin D<20 ng/ml (HR 5.4517, (95 % CI 2.3167–11.8209), p1.45 mmol/l (HR0.0821, (95 % CI0.0042–1.5920), p=0.0439). The lowest occurrence of PTDM and proteinuria was recorded in patients whose treatment included paricalcitol (p<0.0001) and these patients had at the same time the highest level of vitamin D (p<0.0001).
CONCLUSION: Deficit of vitamin D, proteinuria and hyperphosphatemia have been independent risk factors for the development of PTDM in our set. We identified the usage of paricalcitol as protective factor with regard to the PTDM development (Tab. 6, Fig. 4, Ref. 29).

Keywords: post-transplant diabetes mellitus, proteinuria, vitamin D, paricalcitol, kidney transplantation.
Published online: 17-Jul-2018
Year: 2018, Volume: 119, Issue: 7 Page From: 401, Page To: 407

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