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Bratislava Medical Journal 2018 Bratislava Medical Journal Vol.119, No.7, p.421–424, 2018
Bratislava Medical Journal 2018 Bratislava Medical Journal Vol.119, No.7, p.421–424, 2018
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Bratislava Medical Journal Vol.119, No.7, p.421–424, 2018 |
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| Title: The novel diagnostic marker in low-LVEF heart failure patients | ||
| Author: S. Demir, H. Ede, M. Kaplan, F. Yavuz, C. Yucel, I. H. Kurt | ||
| Abstract: OBJECTIVE: The structural and compositional changes in the myocardium seem to have a major role in the development of heart failure (HF).Imbalance between production and degradation in extracellular collagen results in increase of collagen synthesis biomarkers in the circulation as the carboxy-terminal propeptide of type I procollagen (PIP). Here we aimed to determine role of PIP in the diagnosis of chronic HF. MATERIAL AND METHODS: 87 patients with HF group and 80 healthy subjects were enrolled into the study. Echocardiographic examination was performed.At the beginning of the study, serum B type natriuretic peptide (BNP), PIP, high sensitive C-reactive protein (hs-CRP) were measured . The subjects were followed for one year then after. RESULTS:Average PIP value of HF group was significantly higher than that of the control group (p < 0.001). Both hs-CRP and BNP values were well correlated to PIP values (p < 0.001). In the HF group, PIP value of patients who died at the end of one year was similar to that of patients who survived at the end of first year. CONCLUSION: PIP may not mirror acute events in follow-up of chronic heart failure but it is a very beneficial biomarker in diagnosis of low-LVEF heart failure with high sensitivity and specificity (Tab. 2, Fig. 1, Ref. 16). |
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| Keywords: PIP, BNP, hs-CRP | ||
| Published online: 17-Jul-2018 | ||
| Year: 2018, Volume: 119, Issue: 7 | Page From: 421, Page To: 424 | |
| doi:10.4149/BLL_2018_076 |
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