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Bratislava Medical Journal 2018 Bratislava Medical Journal Vol.119, No.7, p.441–443, 2018
Bratislava Medical Journal 2018 Bratislava Medical Journal Vol.119, No.7, p.441–443, 2018
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Bratislava Medical Journal Vol.119, No.7, p.441–443, 2018 |
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| Title: Effect of cerium oxide on erythrocyte deformability in rat lower extremity ischemia reperfusion injury | ||
| Author: T. Tatar, Y. Polat, F. M. Comu, H. Kartal, M. Arslan, A. Kucuk | ||
| Abstract: BACKGROUND: Cerium oxide is the oxide form of cerium, which has protective effects in ischemia reperfusion (I/R) injury. The purpose of our study was to look into the effects of this rare-earth metal on erythrocyte deformability in rat lower extremity I/R injury model. MATERIALS AND METHODS: We used 24 Wistar albino rats as subjects in our study. They were divided into 4 groups; randomized control group (group C; n = 6), cerium oxide group 0.5 mg.kg–1, intraperitoneal (group CO; n = 6), I/R group (group I/R; n = 6) and I/R group with cerium oxide 0.5 mg.kg–1 intraperitoneally (group I/R-CO; n = 6). Erythrocyte packs were prepared from heparinized blood samples and deformability measurements were performed. RESULTS: We obtained similar results from the control and I/R-CO groups (p = 0.158). The results in I/R group were evidently higher than those of the control, CO, and IR-CO groups (p < 0.0001, p < 0.0001, p = 0.001, respectively). CONCLUSION: We detected unfavorable effects of I/R on erythrocyte deformability, which may impair blood flow and hence tissue perfusion in infrarenal rat aorta. We also found that cerium oxide had beneficial effects by reversing undesirable effects of I/R. Further studies with larger volume are required to support our promising results (Fig. 1, Ref. 24). |
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| Keywords: erythrocyte deformability, ischemia reperfusion, cerium oxide, rat | ||
| Published online: 17-Jul-2018 | ||
| Year: 2018, Volume: 119, Issue: 7 | Page From: 441, Page To: 443 | |
| doi:10.4149/BLL_2018_080 |
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