Home CUSTOMERS Neoplasma 2018 Neoplasma Vol.65, No.4, p.532-541, 2018

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

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Neoplasma Vol.65, No.4, p.532-541, 2018

Title: LINGO1, C7orf31 and VEGFA are prognostic genes of primary glioblastoma: analysis of gene expression microarray
Author: S. LIU, Y. XU, S. ZHANG

Abstract: Glioblastoma is the most prevalent malignant glioma in WHO grade IV and its median overall survival is 12–15 months. This study identifies the primary glioblastoma. prognostic genes. Gene expression data in primary glioblastomas with short-term (36 months, N=23) overall survival were downloaded from Gene Expression Omnibus (GSE53733). Limma determined the differentially expressed genes (DEGs) between different groups (|log2 fold change| ≥0.5 and p-value DEG’s degree, betweenness, sub-graph and closeness centralities. Long- term/short-term survival-related DEGs were defined as those with increased/decreased expression values and survival time. The following DEGs were identified; 161 between intermediate and short-term glioblastomas, 465 between long-term and short-term and 624 between long-term and intermediate tumors. The common FLRT1 and LINGO1 up-regulated DEGs and common down-regulated C7orf31 were identified in these three DEG sets. PPI networks were established, and VEGFA was the key DEG in each PPI network. The short-term survival-related DEGs were enriched in 3 cancer-related pathways. Moreover, FLRT1 and LINGO1 were long-term survival-related DEGs and C7orf31 and VEGFA were short-term survival DEGs. LINGO1, C7orf31, and VEGFA were confirmed using a further dataset, and we therefore conclude that LINGO1 might be a positive primary glioblastoma prognostic gene and C7orf31 and VEGFA might be negative prognosticators.

Keywords: erentially expressed gene, overall survival, primary glioblastoma, prognosis, protein–protein interaction
Published online: 30-Jul-2018
Year: 2018, Volume: 65, Issue: 4 Page From: 532, Page To: 541

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