Home CUSTOMERS Neoplasma 2018 Neoplasma Vol.65, No.4, p.561-571, 2018

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

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Neoplasma Vol.65, No.4, p.561-571, 2018

Title: Flotillin 1 is differentially expressed in human epithelial ovarian tumors
Author: J. LI, X. ZUO, J. SHI, J. ZHANG, X. DUAN, G. XU

Abstract: Although Flotillin 1 (FLOT1) is highly expressed in various human cancers, its relationship with ovarian cancer (OC) remains unknown. This study determines FLOT1 expression in human ovarian tumors and examines its effect on OC   cell proliferation. FLOT1 protein expression was assessed in a tissue microarray by immunohistochemical staining. We found that 81.48% malignant and 50% borderline tumors were FLOT1 protein-positive, whereas benign tumors and normal ovarian tissues were negative. The staining was strongest in serous malignant tumor and transitional cell carcinoma and weakest in mucinous tumor. Differentially expressed FLOT1 in freshly isolated serous tumors was confirmed by Western blot and we then evaluated FLOT1 expression association with OC patients’ clinical characteristics. Histological typing established that FLOT1 protein expression was significantly associated with serous tumor (P

Keywords: cell proliferation, epithelial ovarian cancer, FLOT1, miRNA, therapeutic target, tumorigenesis
Published online: 30-Jul-2018
Year: 2018, Volume: 65, Issue: 4 Page From: 561, Page To: 571

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