Home FOR AUTHORS Neoplasma 2018 Neoplasma Vol.65, No.4, p.579-584, 2018

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Neoplasma Vol.65, No.4, p.579-584, 2018

Title: Deep inside of gastric signet-ring cell carcinoma
Author: L. RONCATI, A. MANENTI, G. BARBOLINI, A. MAIORANA
Abstract: The histology of signet-ring cell carcinoma (SRC) of the stomach has been revisited with the support of current immuno- histochemical techniques in order to explain particular features of this tumor; its great capacity of local diffusion and lymph node metastasis, also through a neo-lymphoangiogenesis. An observational retrospective study on 50 cases of SRC in stage II and III has been performed with the addition of histochemical (Alcian Blue, DDD-Fast Blue B, Mercury Orange) and immunohistochemical (cytocheratin, CD3, CD4, CD8, CD10, CD56, CD68, perforin, granzyme B, podoplanin, collagen type IV) investigations for each case. The signet ring cells, typical for this tumor, show abundant content of electro-negative sialomucins and demonstrate a great capacity of diffusion through the gastric wall. They evoke production and deposition of collagen type IV in the sub-mucosa layer through the local action of fibroblasts. The immunological response to this tumor in the gastric wall and in the metastatic lymph nodes is represented by an increase of B and T-helper lymphocytes, but not of T-killers or natural killers. The neoplastic cells are curiously able to avoid these newly formed ‘lymph nodules’. An extended neo-lymphangiogenesis has been observed around the primary tumor and in metastatic lymph nodes. A careful immunohistochemical characterization has allowed a better knowledge of SRC, regarding especially the peculiar behavior of local diffusion of its cells, the associated neo-lymph angiogenesis, and poor immunological reaction.
Keywords: undiff erentiated gastric carcinoma, signet-ring cell carcinoma, lymphangiogenesis, tumor-infi ltrating lymphocytes, cancer, histology
Published online: 30-Jul-2018
Year: 2018, Volume: 65, Issue: 4 Page From: 579, Page To: 584
doi:10.4149/neo_2018_170404N246


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