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HOME Acta Virologica 2018 Acta Virologica Vol.62, No.3, p.333-336, 2018
HOME Acta Virologica 2018 Acta Virologica Vol.62, No.3, p.333-336, 2018
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Acta Virologica Vol.62, No.3, p.333-336, 2018 |
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| Title: Quantitative and rapid interference of bovine viral diarrhea virus BVDV/END– and BVDV/END+ strains | ||
| Author: M. MUHSEN, P. LEE | ||
| Abstract: Homologous interference in vitro is defined as the ability of primary viral infection to prevent secondary homologous superinfection. Non-cytopathic bovine viral diarrhea virus (ncp BVDV) has been classified according to the exaltation of Newcastle disease phenomenon (END) as END positive (E+) and END negative (E–) strains. Simultaneous inoculation of MDBK-SY cell monolayers with BVDV/E– virus and a three log higher amount of BVDV RK13/E+ virus, leads to acquisition of the BVDV/E– feature of blocking Newcastle disease virus (NDV) infection in cells. BVDV/E– strains, particularly at a high titre and MOI ≥1.25, can exert and impose their effects in BVDV/E+ infected cells; however, if BVDV/E– MOI is reduced to MOI below 0.625, the BVDV/E+ effect can be restored leading to cytopathic effects (CPE) induction by NDV reciprocal to the titre of the BVDV RK13/E+ strain. Moreover, blocking and prevention of induced CPE by NDV or vesicular stomatitis virus (VSV) occurs even when BVDV/E– superinfects primary BVDV/E+ infected cells, indicating a defective homologous interference between BVDV/E+ and BVDV/E– strains. Taken together, BVDV/E– strains have a strong competitive potency and mediate a fast acting (i.e. within 60 min) influence against BVDV/E+ activity. This may be relevant in vivo where BVDV/E– and BVDV/E+ combinations are frequently isolated from infected individuals. |
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| Keywords: BVDV; END phenomenon; homologous interference; NDV; VSV | ||
| Published online: 30-Aug-2018 | ||
| Year: 2018, Volume: 62, Issue: 3 | Page From: 333, Page To: 336 | |
| doi:10.4149/av_2018_228 |
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