Home Neoplasma 2018 Neoplasma Vol.65, No.5, p.664-672, 2018

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

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Neoplasma Vol.65, No.5, p.664-672, 2018

Title: Long non-coding RNA EPB41L4A-AS2 inhibited non-small cell lung cancer proliferation and invasion and promoted cell apoptosis
Author: J. SHU, S. LI, Y.B. CHEN, Q.F. ZHU, X.H. YU

Abstract: This research investigates the expression of lncRNA EPB41L4A-AS2 in non-small cell lung cancer (NSCLC) and evaluates its influence on the proliferation, invasion and apoptosis of NSCLC. A total of 56 NSCLC tissues and corresponding adjacent tissue was collected. Quantitative Reverse transcription polymerase chain reaction (qRT-PCR) evaluated the lncRNA EPB41L4A-AS2 expression level in tissues and cell lines, and proliferating cell nuclear antigen (PCNA) protein level was determined by western blot assay. CCK8 assay, EdU assay, flow cytometry (FCM) and transwell assay were performed to access cell proliferation, apoptosis and invasion. EPB41L4A-AS2 expression was significantly down-regulated in cancer tissues and cells compared with adjacent tissues and normal cells (P

Keywords: NSCLC; LncRNA EPB41L4A-AS2; proliferation; apoptosis; invasion
Published online: 24-Sep-2018
Year: 2018, Volume: 65, Issue: 5 Page From: 664, Page To: 672
doi:10.4149/neo_2018_170713N480
Price: 21.60 €






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