Home 
Bratislava Medical Journal 2018 Bratislava Medical Journal Vol.119, No.8, p.490–493, 2018
Bratislava Medical Journal 2018 Bratislava Medical Journal Vol.119, No.8, p.490–493, 2018
Journal info
|
||||
Select Journal
Journals
Bratislava Medical Journal 2024 Ahead of print 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 Endocrine Regulations General Physiology and Biophysics Neoplasma Acta Virologica Studia Psychologica Cardiology Letters Psychológia a patopsych. dieťaťa Kovove Materialy-Metallic Materials Slovenská hudbaWebshop Cart
Your Cart is currently empty.
Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.
Bratislava Medical Journal Vol.119, No.8, p.490–493, 2018 |
||
| Title: Evaluation of pentraxin-3 in familial Mediterranean fever patients during attack and attack-free periods | ||
| Author: M. Gok, O. Sirkeci, M. Kara, Y. S. Sakin, A. Tanoglu, E. E. Sirkeci, H. Oztin, T. Duzenli, M. Kaplan, Y. Yazgan, O. M. Ipcioglu | ||
| Abstract: INTRODUCTION: Pentraxin-3 (PTX-3) is a prototype of pentraxin proteins that have been shown to be involved in acute phase response. In this study, we aimed to investigate the relationship between PTX-3 levels and familial Mediterranean fever (FMF) disease, and to evaluate PTX-3 as a novel diagnostic marker of FMF. METHOD: Forty-three male patients diagnosed with FMF and 42 healthy individuals were included in the study. Patients with other inflammatory diseases and patients who used drugs having anti-inflammatory properties were excluded from the research. Blood samples were obtained during both attack and attack-free periods. RESULTS: Patient attack periods were confirmed by combining physical examination and elevation of acute phase reactants. Acute phase reactants were significantly higher in attack versus attack-free periods (p < 0.01), however PTX-3 levels were not significantly different between the two periods. Additionally, PTX-3 levels in FMF patients were higher than in controls in both attack (917.29 ± 725.29 vs 451.83 ± 291.95, p < 0.01) and attack-free periods (748.23 ± 487.53 vs 451.83 ± 291.95, p < 0.01). CONCLUSION: In this study, we showed that PTX-3 levels, in both FMF attack and attack-free periods, were significantly higher than in the control group. Finally, PTX-3 may be a promising biomarker for FMF diagnosis and may predict FMF attacks (Tab. 2, Fig. 2, Ref. 18). |
||
| Keywords: familial Mediterranean fever, pentraxin-3, inflammation | ||
| Published online: 30-Aug-2018 | ||
| Year: 2018, Volume: 119, Issue: 8 | Page From: 490, Page To: 493 | |
| doi:10.4149/BLL_2018_089 |
||
|
|
 download file |
|