Home Bratislava Medical Journal 2018 Bratislava Medical Journal Vol.119, No.8, p.498–502, 2018

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.5

 

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Bratislava Medical Journal Vol.119, No.8, p.498–502, 2018

Title: The relationship between severity of ulcerative colitis and thiol-disulphide homeostasis
Author: S. Neselioglu, P. B. Keske, A. Aydin Senat, O. T. Yurekli, S. Erdogan, M. Alisik, M. S. Ergin, H. Koseoglu, O. Ersoy, O. Erel
Abstract: OBJECTIVES: The aim of the study was to determine dynamic thiol-disulphide homeostasis in patients with ulcerative colitis, compare it with those of healthy control and to investigate the relationship between the severity of the disease and homeostasis
METHODS: A total of 78 patients and 58 healthy subjects were included in the study. Serum native thiol, total thiol and disulphide amounts were measured by using a novel automated method. Obtained results were compared and relationships were determined by correlation analysis.
RESULTS: Serum native thiol, total thiol, disulphide amounts and disulphide/native thiol percent ratio (index) were significantly lower (p = 0.003 for index ratio and p < 0.001 for other parameters) in patients with ulcerative colitis than in healthy controls. Native thiol, total thiol and disulphide amounts were significantly higher (p < 0.001) in patients with ulcerative colitis in remission than in patients with active ulcerative colitis and near to those of healthy control. There were significant negative correlations between the severity of the disease and thiol-disulphide homeostasis parameters (r = –0.55, p < 0.001 for native thiol; r = –0.64, p < 0.0001 for total thiol; r = –0.65, p < 0.001 for disulphide and r = –0.33, p = 0.011 for index).
CONCLUSION: The thiol-disulphide homeostasis was weakened in ulcerative colitis. Strong correlations between the activity of the disease and thiol-disulfide homeostasis indicate that homeostasis may play a role in the pathogenesis of the disease (Tab. 3, Fig. 3, Ref. 30).
Keywords: disulphide, inflammatory bowel disease, thiol; ulcerative colitis
Published online: 30-Aug-2018
Year: 2018, Volume: 119, Issue: 8 Page From: 498, Page To: 502
doi:10.4149/BLL_2018_091


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