Home CUSTOMERS Bratislava Medical Journal 2018 Bratislava Medical Journal Vol.119, No.8, p.513–515, 2018

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.564


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Bratislava Medical Journal Vol.119, No.8, p.513–515, 2018

Title: Incomprehensible treatment of retinoblastoma with high doses of vitamin C
Author: D. Tomcikova, A. Gerinec, B. Busanyova, K. Husakova, M. Kuniak, R. Autrata

Abstract: PURPOSES: To inform about a case of neglected retinoblastoma that was left untreated for more than 3 years by parents. During this time period the local finding worsened from endophytic retinoblastoma group B according IIRC (ABC classification) to extraorbital propagation.
BACKGROUND: Retinoblastoma is the most common intraocular tumor in childhood, that occurs approximately in 1 : 15–20 000 births worldwide. In European region cases of extraocular propagation are very infrequent. Extraorbital propagation is extremely rare in middle and high income countries.
METHODS: We report the preoperative ophthalmological findings, MRI imaging, treatment methods and postoperative results of this case.
RESULTS: After initial dose of six courses of chemotherapy patient underwent surgery (orbital exenteration). In postoperative period patient received two more courses of chemotherapy. In spite of progressed stage of the disease, we obtained good results with our therapy.
CONCLUSIONS: We suppose that good treatment results, in spite of extraordinary long lag interval and hopeless pretreatment condition, caused by alternative therapy with high doses vitamin C and no protein intake, were caused by therapeutic naïve retinoblastoma with an absence of RB1 gene mutation (Fig. 6, Ref. 7).

Keywords: extraorbital retinoblastoma, treatment, high doses of vitamin C, exenteration, RB1 gene
Published online: 30-Aug-2018
Year: 2018, Volume: 119, Issue: 8 Page From: 513, Page To: 515

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