Home General Physiology and Biophysics 2018 General Physiology and Biophysics Vol.37, No.5, p.515–525, 2018

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Quarterly, 80 pp. per issue
Founded: 1982
ISSN  1338-4325 (online)

Published in English

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General Physiology and Biophysics Vol.37, No.5, p.515–525, 2018

Title: The perfusion of cisplatin and cisplatin structural analogues through the isolated rat heart: The effects on coronary flow and cardiodynamic parameters
Author: I. M. Stojic, V. Lj. Jakovljevic, V. I. Zivkovic, I. M. Srejovic, T. R. Nikolic, J. N. Jeremic, N. S. Jeremic, D. M. Djuric, K. G. Radonjic, M. Labudovic-Borovic, Z. D. Bugarcic, J. Bogojeski, S. S. Novokmet

Abstract: The therapeutic use of cisplatin for the treatment of solid tumours is associated with organ toxicity. Amongst those, the cardiotoxicity is an occasional but very serious and severe side effect. To prevent or reduce these negative effects, many cisplatin analogues have been synthesized and evaluated in terms of being a less toxic and more effective agent. In present study, we examined the effects of cisplatin and its three analogues in the isolated rat heart to determine whether changes in the structure of the platinum complexes (changing of carrier ligands – ethylenediamine; 1,2-diaminocyclohexane; 2,2’:6’,2’’-terpyridine) can influence their cardiotoxic effects. The results of our research indicate that the introduction of aromatic rings in the structure of the platinum complexes has a negative influence on the heart function. Conversely, the other two examined complexes had less negative effects on heart function compared to cisplatin. Our findings may be of interest for a possible synthetic strategy of introducing a carrier ligand that will exert a less cardiotoxic effect.

Keywords: Cardiac function, Cardiotoxicity, Cisplatin, Isolated-perfused heart, Metal toxicity, Platinum(II) complexes
Published online: 02-Oct-2018
Year: 2018, Volume: 37, Issue: 5 Page From: 515, Page To: 525

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