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neo_2018_170720N491

Title: Meta-analysis of the association of IGFBP3 and IGF1 polymorphisms with susceptibility to colorectal cancer
Author: W. Wang, B. Q. Wu, G. B. Chen, Y. Zhou, Z. H. Li, J. L. Zhang, Y. L. Ding, P. Zhang, J. Q. Wang

Abstract:

The aim of this study is to comprehensively evaluate the associations of IGFBP3 and IGF1 polymorphisms with susceptibility to colorectal cancer (CRC). We searched the English and Chinese databases and recruited case-control studies based on strict inclusion and exclusion criteria. The statistical analysis was performed by the Comprehensive Meta-analysis 2.0 (CMA 2.0) software and this initially identified 251 studies. We then recruited 10 English studies to this meta-analysis detailed review which includes 9,415 CRC patients and 14,179 healthy controls. Our results demonstrated that IGFBP3 rs2854746 C>G polymorphism increases susceptibility to the CRC (allele model: OR = 1.167, 95% CI = 1.095~1.244, P T polymorphism decreases susceptibility to CRC (allele model: OR = 0.785, 95% CI = 0.726~0.850, P < 0.001 and also the dominant model: OR = 0.730, 95% CI = 0.661~0.806, P < 0.001).

However, IGFBP3 rs2854746 C>G is considered the susceptible CRC polymorphism and IGF1 rs35767 C>T is CRC protective.



Keywords: IGFBP3, IGF1, rs2854746 C>G, rs35767 C>T, polymorphism, colorectal cancer
Published online: 08-Oct-2018
Year: , Volume: , Issue: Page From: , Page To:
doi:10.4149/neo_2018_170720N491


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