Journal info
|
||
Select Journal
Journals
Bratislava Medical Journal Endocrine Regulations General Physiology and Biophysics Neoplasma 2024 Ahead of print 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 Acta Virologica Studia Psychologica Cardiology Letters Psychológia a patopsych. dieťaťa Kovove Materialy-Metallic Materials Slovenská hudbaWebshop Cart
Your Cart is currently empty.
Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.
Neoplasma Vol.66, No.1, p.20-27, 2019 |
||
Title: The aberrant activation of the Wnt pathway caused by β-catenin mutation and its prognostic significance in NK/T-cell lymphoma | ||
Author: B. B. Qin, D. F. Tang, M. L. Ni, W. Gao, M. Z. Zhang | ||
Abstract: The aberrant activation of the Wnt/β-catenin signal has an important role in the progression of cancers. Herein, we investigated β-catenin mutation and the activation of the Wnt pathway in association with the clinical-pathological characteristics, chemo-resistance and prognosis of NK/T-cell lymphoma (NKTCL). Real-time quantitative PCR, immunocytochemistry and immunohistochemistry SP methods detected the levels of β-catenin, c-myc and cyclin D1 in human NKTCL cell lines (SNK-6 and YTS) and NKTCL tissues. Mutation analysis was detected in exon 3 of β-catenin gene; and we analyzed cell viability after histone deacetylase inhibitor (HDACi) treatment. As a result, 19 (38%) of NK/T-cell lymphoma displayed nuclear β-catenin and 16 (32%) contained mutations in exon 3; while no mutations were detected in lymphomas negative for β-catenin nuclear staining (p NKTCL patients. |
||
Keywords: NK/T cell lymphoma, Wnt pathway, β-catenin mutation, chemoresistence, prognosis | ||
Published online: 22-Jan-2019 | ||
Year: 2019, Volume: 66, Issue: 1 | Page From: 20, Page To: 27 | |
doi:10.4149/neo_2018_170929N619 |
||
|
download file |
|