Home HOME Neoplasma 2019 Neoplasma Vol.66, No.1, p.20-27, 2019

Journal info

6 times a year.
Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

Published in English

Editorial Info
Abstracted and Indexed
Submission Guidelines

Select Journal

Webshop Cart

Your Cart is currently empty.

Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.

Neoplasma Vol.66, No.1, p.20-27, 2019

Title: The aberrant activation of the Wnt pathway caused by β-catenin mutation and its prognostic significance in NK/T-cell lymphoma
Author: B. B. Qin, D. F. Tang, M. L. Ni, W. Gao, M. Z. Zhang

Abstract: The aberrant activation of the Wnt/β-catenin signal has an important role in the progression of cancers. Herein, we investigated β-catenin mutation and the activation of the Wnt pathway in association with the clinical-pathological characteristics, chemo-resistance and prognosis of NK/T-cell lymphoma (NKTCL). Real-time quantitative PCR, immunocytochemistry and immunohistochemistry SP methods detected the levels of β-catenin, c-myc and cyclin D1 in human NKTCL cell lines (SNK-6 and YTS) and NKTCL tissues. Mutation analysis was detected in exon 3 of β-catenin gene; and we analyzed cell viability after histone deacetylase inhibitor (HDACi) treatment. As a result, 19 (38%) of NK/T-cell lymphoma displayed nuclear β-catenin and 16 (32%) contained mutations in exon 3; while no mutations were detected in lymphomas negative for β-catenin nuclear staining (p NKTCL patients.

Keywords: NK/T cell lymphoma, Wnt pathway, β-catenin mutation, chemoresistence, prognosis
Published online: 22-Jan-2019
Year: 2019, Volume: 66, Issue: 1 Page From: 20, Page To: 27

download file

© AEPress s.r.o
Copyright notice: For any permission to reproduce, archive or otherwise use the documents in the ELiS, please contact AEP.