Home CONTACT Neoplasma 2019 Neoplasma Vol.66, No.1, p.73-82, 2019

Journal info


6 times a year.
Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

Published in English

Editorial Info
Abstracted and Indexed
Submission Guidelines

Select Journal







Webshop Cart

Your Cart is currently empty.

Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.

Neoplasma Vol.66, No.1, p.73-82, 2019

Title: The prognostic role of long noncoding RNA CRNDE in cancer patients: a systematic review and meta-analysis
Author: W. Wang, F. Yuan, J. Xu

Abstract: The novel colorectal neoplasia differentially expressed lncRNA (CRNDE) has been discovered in many solid tumors. We conducted this systematic review and meta-analysis to illuminate the function of CRNDE in cancer. Published articles were identified by electronic search of PubMed, EMBASE, and MEDLINE using the keywords “cancer or carcinoma or neoplasm or tumor” and “long noncoding RNA CRNDE or noncoding RNA CRNED or CRNDE”. Hazard ratios (HRs), standard errors (SEs) and their corresponding 95% confidence intervals (CIs) were estimated from study survival curves. Odds ratios (ORs) with 95% CIs were estimated in order to evaluate the correlation between CRNDE expression level and cancer patient clinical outcome. Herein, 13 of the 49 identified studies completely fulfilled inclusive criteria for this systemic review. The results are as follows: the pooled HR of high expression versus low expression of CRNDE was 1.64 with a 95% CI of [1.44, 1.87]; the pooled OR of high CRNDE expression in early TNM stages versus late TNM stages was 0.35 with a 95% CI of [0.26, 0.47]; the pooled OR of high CRNDE expression in positive lymph node metastasis versus negative lymph node metastasis was 3.62 with a 95% CI of [1.99, 6.58]; the pooled OR of high CRNDE expression in tumor size larger than 5 cm versus tumor size smaller than 5 cm was 2.99 with a 95% CI of [1.13, 7.93]. For colorectal cancer studies, the pooled OR of high CRNDE expression in colon tumor versus rectal tumor was 1.18 with a 95% CI of [0.64, 2.18], the pooled OR of high CRNDE expression among T1 and T2 versus T3 and T4 was 0.91 with a 95% CI of [0.57, 1.46], and the pooled OR of high CRNDE expression in colorectal cancer patients without distant metastasis versus patients with distant metastasis was 0.48 with a 95% CI of [0.21, 1.10]. No obvious publication bias was observed in any study in this meta-analysis.
CRNDE was confirmed an oncogene, and its up-regulated expression significantly correlated with poor prognosis and advanced tumor progression.

Keywords: CRNDE, prognosis, systematic review, meta-analysis
Published online: 22-Jan-2019
Year: 2019, Volume: 66, Issue: 1 Page From: 73, Page To: 82
doi:10.4149/neo_2018_180320N191


download file



© AEPress s.r.o
Copyright notice: For any permission to reproduce, archive or otherwise use the documents in the ELiS, please contact AEP.