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HOME Bratislava Medical Journal 2018 Bratislava Medical Journal Vol.119, No.10, p.613–618, 2018
HOME Bratislava Medical Journal 2018 Bratislava Medical Journal Vol.119, No.10, p.613–618, 2018
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Bratislava Medical Journal Vol.119, No.10, p.613–618, 2018 |
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| Title: The influence of interferon-γ on cardiac and renal histopathological changes induced by carbamazepine | ||
| Author: S. Bahmanpour, F. Karimi, A. Soleimani, M. Kamali, M. R. Namavar | ||
| Abstract: BACKGROUND: Carbamazepine (CBZ) is used for the treatment of epileptic seizures. This study was designed to evaluate the effect of Interferon-gamma on the fetal heart and kidney histopathological changes of CBZ-treated pregnant mice. METHODS: Twenty pregnant mice were divided into four groups. The control group received distilled water. The second group received 240 mg/kg of CBZ by gastric gavage. The third group received intraperitoneal injection (IP) of IFN-γ. The fourth group received IP injection of IFN-γ with 240 mg/kg CBZ by gavage. The fetuses were delivered by hysterectomy on the 18th day of gestation. RESULTS: The mean weight, crown-rump length, the total volume of the heart and kidney of the fetuses in the CBZ-treated group were significantly reduced when compared with the control, INF-γ and CBZ + INF-γ groups (p < 0.05). INF-γ prevented histopathological changes when used with CBZ (p < 0.05). CONCLUSION: CBZ induced structural changes in the fetal tissues of the pregnant mice. However, IFN-γ could reduce these changes (Tab. 1, Fig. 4, Ref. 26). |
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| Keywords: carbamazepine, interferon-γ, heart, kidney, mice | ||
| Published online: 18-Oct-2018 | ||
| Year: 2018, Volume: 119, Issue: 10 | Page From: 613, Page To: 618 | |
| doi:10.4149/BLL_2018_109 |
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