Home Bratislava Medical Journal 2018 Bratislava Medical Journal Vol.119, No.10, p.651–654, 2018

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345
 

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Bratislava Medical Journal Vol.119, No.10, p.651–654, 2018

Title: Association between interleukin 4 (IL-4) VNTR, gene polymorphism, and breast cancer susceptibility in Iranian population: experimental and web base analysis
Author: M. Ibrahimi, B. Jamalzei, M. E. Akbari, R. Ibrahimi, M. Alaei, M. Moossavi, M. Mohammadoo-Khorasani

Abstract: BACKGROUND: Breast cancer (BC) is one of the most common types of cancer and the second leading cause of cancer death among women. Epidemiological studies showed that BC is linked to genetic and environmental factors, and inheritance plays a key role in the pathobiology of this disease. Interleukin 4 (IL-4) is a key differentiation cytokine and is produced by Th2 and activates Th2 development. Hence the current study aimed to assess the possible association between interleukin 4 (IL-4) VNTR polymorphism, and BC susceptibility in a sample of Iranian population.
MATERIAL AND METHODS: IL-4 VNTR polymorphism was evaluated in 150 women with BC and 150 age-matched healthy women by polymerase chain reaction method.
RESULT: Among 3 possible alleles for IL-4 gene, we only observed 2 alleles. Current findings indicate that RP2/RP2 genotypes can be regarded as potent protective factors against breast cancer (OR = 0.929 [95%CI, 0.929–0.995]).
CONCLUSION: Our result showed that the RP2/RP2 genotype of the IL-4 VNTR polymorphism could be a protective factor for BC susceptibility (Tab. 2, Fig. 1, Ref. 46).

Keywords: IL-4, breast cancer, VNTR polymorphism
Published online: 20-Oct-2018
Year: 2018, Volume: 119, Issue: 10 Page From: 651, Page To: 654
doi:10.4149/BLL_2018_116


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