Home HOME Endocrine Regulations 2008 Endocrine Regulations Vol.42, p.39-44, 2008

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Quarterly, 50 pp. per issue 
Founded: 1967
ISSN 1210-0668
E-ISSN 1336-0329

Published in English

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Endocrine Regulations Vol.42, p.39-44, 2008

Title: THE IMPACT OF PARATHYROID GLAND AUTOTRANSPLANTATION DURING BILATERAL THYROID SURGERY FOR GRAVES´ DISEASE ON POSTOPERATIVE HYPOCALCAEMIA
Author: E. KARAKAS, T. OSEI-AGYEMANG, K. SCHLOSSER, S. HOFFMANN, A. ZIELKE, M. ROTHMUND, I. HASSAN

Abstract: Objective. The aim of this study was to compare the rate of hypocalcaemia after bilateral thyroid resection for Graves’ Disease in patients with and without parathyroid gland autotransplantation (PTAT). Patients and Methods. A total of 153 patients following thyroid surgery for Graves’ disease were studied. Patients were divided into three groups. Subgroup I comprised of 129 patients without PTAT, Subgroup II comprised of 19 patients with PTAT of one parathyroid gland and Subgroup III comprised of 6 patients with PTAT of two parathyroid glands. Association between PTAT and postoperative hypocalcaemia (PH) after thyroidectomy was investigated. Results. There were 27/128 (21.1 %) patients with transient and 10/128 (7.8 %) patients with permanent hypocalcemia within Subgroup I. Among Subgroup II 4/19 (21.1 %) patients developed transient and no patient developed permanent hypocalcaemia, while in Subgroup III 2/6 (33.3 %) patients developed transient hypocalcaemia which became persistent. Thus, the frequency of permanent postthyroidectomy hypocalcaemia (PH) was significantly higher in the Subgroup III with PTAT of two parathyroid glands when compared to the Subgroup I without PTAT (p=0.032) and Subgroup II with PTAT of only one parathyroid glands (p=0.012). Conclusion. PTAT of one parathyroid gland is an effective procedure to reduce the incidence of permanent hypoparathyroidism after bilateral surgery for Graves disease. Transient hypoparathyroidism was not influenced by PTAT.

Keywords: Graves´ disease – Hypoparathyroidism – Endocrine Ophthalmopathy – Cross sectional study – NOSPECS
Year: 2008, Volume: 42, Issue: 2 Page From: 39, Page To: 44



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