Home HOME General Physiology and Biophysics 2018 General Physiology and Biophysics Vol.37, No.6, p.657–666, 2018

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Quarterly, 80 pp. per issue
Founded: 1982
ISSN  1338-4325 (online)

Published in English

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General Physiology and Biophysics Vol.37, No.6, p.657–666, 2018

Title: Exercise training and dietary restriction affect PINK1/Parkin and Bnip3/Nix-mediated cardiac mitophagy in mice
Author: Y. Zhao, Q. Zhu, W. Song, B. Gao

Abstract: The aim of this study was to investigate the effects of exercise training and dietary restriction on cardiac PINK1/Parkin and Bnip3/Nix pathways involved in mitophagy. C57BL/6 mice were assigned to control (C), exercise training (T), dietary restriction (D) and exercise training + dietary restriction (TD) groups. T group undertook 10 weeks of swimming training. D group was subjected to 40% food reduction. TD group undertook the combination of exercise training and food reduction. Suspectable mitophagy autophagosomes can be observed in T and D groups and more autophagosomes appeared in TD group. In T group, both PINK1 mRNA and protein levels increased significantly (p

Keywords: Swimming, Mitochondrial autophagy, Cardiomyocyte, Calorie restriction
Published online: 28-Nov-2018
Year: 2018, Volume: 37, Issue: 6 Page From: 657, Page To: 666
doi:10.4149/gpb_2018020


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