General Physiology and Biophysics Vol.37, No.6, p.703

General Physiology and Biophysics Vol.37, No.6, p.703–710, 2018

Founded: 1982
ISSN 1338-4325 (online)
ISSN 0231-5882 (print)
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General Physiology and Biophysics Vol.37, No.6, p.703–710, 2018
Title: Relationship of epigenetic variability of miR-124 to extracellular matrix remodelling and age-related MMP-3 expression in rheumatoid arthritis
Author: Monika Pávková Goldbergová, Jolana Lipková, Jan Fedorko, Petr Němec, Jindřiška Gatterová, Lucie Válková, Jana Ševčíková, Anna Vašků

Abstract: The aim of study was to examine relation among miR-124 and serum levels of selected cytokines and chemokines, MMP-3, production of auto-antibodies, and factors describing clinical activity (DAS28) and radiographic progression in rheumatoid arthritis (RA). A total of 80 RA patients according to the ACR classification criteria, and 32 control subjects were recruited into study. The measurements of miR-124 and U-6 expression, CRP, anti-CCP, rheumatoid factors (RFs), radiographs of both hands with calculation of total sharp score (TSS), DAS28 and cytokines, chemokines and MMP levels in serum were obtained from all RA patients. miR-124 was down-regulated in RA patients compared to controls (7-fold decrease). The miR-124 expression correlated to MMP-3 levels (p

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	Published online: 28-Nov-2018
Year: 2018, Volume: 37, Issue: 6	Page From: 703, Page To: 710
doi:10.4149/gpb_2018024
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