General Physiology and Biophysics Vol.37, No.6, p.711

General Physiology and Biophysics Vol.37, No.6, p.711–713, 2018

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General Physiology and Biophysics Vol.37, No.6, p.711–713, 2018
Title: Inhibition of cytochrome P450 by proadifen diminishes the excitability of brain serotonin neurons in rats
Author: D. Grinchii, R. Paliokha, V. Tseilikman, E. Dremencov

Abstract: The aim of this study was to investigate the effect an inhibitor of cytochrome-P450, proadifen hydrochloride (SKF525), on the excitability of serotonin neurons. Adult male Wistar rats were administered SKF525 forty-eight, twenty-four, and one hour before electrophysiological assessments. Control animals were injected saline. Rats were anesthetized with chloral hydrate and glass electrodes were stereotaxically inserted into the dorsal raphe nucleus (DRN). Serotonin neurons were identified and their firing activity was recorded. It was found that the SKF525 inhibits the excitability of 5-HT neurons. We suggest that corticosterone might play a key role in the SKF525-induced inhibition of 5-HT neurons.

Keywords: Serotonin, Dorsal raphe nucleus, in vivo electrophysiology, Proadifen hydrochloride, Cytochrome P450, Corticosterone
	Published online: 28-Nov-2018
Year: 2018, Volume: 37, Issue: 6	Page From: 711, Page To: 713
doi:10.4149/gpb_2018040
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