Home Bratislava Medical Journal 2018 Bratislava Medical Journal Vol.119, No.11, p.684–691, 2018

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345
 

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Bratislava Medical Journal Vol.119, No.11, p.684–691, 2018

Title: Evaluation of the effect of BMSCs condition media and methylprednisolone in TGF-β expression and functional recovery after an acute spinal cord injury
Author: S. Khoshsirat, H. A. Abbaszadeh, B. Ahrabi, M. Bahrami, M. A. Abdollahi far, M. S. Khoramgah, N. A. Roozbahany, S. Darabi

Abstract: The purpose of this experimental study is evaluation of the effect of BMSCs Condition Media and Methylprednisolone in TGF-β expression and functional recovery after acute spinal cord injury in adult wistar rat.
MATERIAL AND METHODS: After an acute spinal cord injury, MP and BMSC-CM were injected intraperitoneally and the recovery rate was evaluated by BBB and narrow beam test. Real time PCR, H[et]E staining, cavity formation and stereology was done after 12 weeks post injury.
RESULT: There were significant differences in functional recovery between MP+CM group, relative to other groups. TGF-β1 expression decreased in MP+CM group compared to the control group. Cavity size in experimental groups decreased compared to the control group. The mean volume of spinal cord demonstrated a significant increase in the MP+CM group in comparison to the other experimental groups.
CONCLUSION: Simultaneous use of MP and BMSC-CM will improve recovery from the spinal cord injury, reduce inflammation and improve functional recovery (Tab. 1, Fig. 8, Ref. 26).

Keywords: spinal cord injury, TGF-β1, inflammation, BMSC, methylprednisolone
Published online: 29-Nov-2018
Year: 2018, Volume: 119, Issue: 11 Page From: 684, Page To: 691
doi:10.4149/BLL_2018_123


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