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HOME Bratislava Medical Journal 2018 Bratislava Medical Journal Vol.119, No.11, p.684–691, 2018
HOME Bratislava Medical Journal 2018 Bratislava Medical Journal Vol.119, No.11, p.684–691, 2018
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Bratislava Medical Journal Vol.119, No.11, p.684–691, 2018 |
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| Title: Evaluation of the effect of BMSCs condition media and methylprednisolone in TGF-β expression and functional recovery after an acute spinal cord injury | ||
| Author: S. Khoshsirat, H. A. Abbaszadeh, B. Ahrabi, M. Bahrami, M. A. Abdollahi far, M. S. Khoramgah, N. A. Roozbahany, S. Darabi | ||
| Abstract: The purpose of this experimental study is evaluation of the effect of BMSCs Condition Media and Methylprednisolone in TGF-β expression and functional recovery after acute spinal cord injury in adult wistar rat. MATERIAL AND METHODS: After an acute spinal cord injury, MP and BMSC-CM were injected intraperitoneally and the recovery rate was evaluated by BBB and narrow beam test. Real time PCR, H[et]E staining, cavity formation and stereology was done after 12 weeks post injury. RESULT: There were significant differences in functional recovery between MP+CM group, relative to other groups. TGF-β1 expression decreased in MP+CM group compared to the control group. Cavity size in experimental groups decreased compared to the control group. The mean volume of spinal cord demonstrated a significant increase in the MP+CM group in comparison to the other experimental groups. CONCLUSION: Simultaneous use of MP and BMSC-CM will improve recovery from the spinal cord injury, reduce inflammation and improve functional recovery (Tab. 1, Fig. 8, Ref. 26). |
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| Keywords: spinal cord injury, TGF-β1, inflammation, BMSC, methylprednisolone | ||
| Published online: 29-Nov-2018 | ||
| Year: 2018, Volume: 119, Issue: 11 | Page From: 684, Page To: 691 | |
| doi:10.4149/BLL_2018_123 |
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