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CONTACT Bratislava Medical Journal 2018 Bratislava Medical Journal Vol.119, No.11, p.713–717, 2018
CONTACT Bratislava Medical Journal 2018 Bratislava Medical Journal Vol.119, No.11, p.713–717, 2018
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Bratislava Medical Journal Vol.119, No.11, p.713–717, 2018 |
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| Title: The ameliorative effect of lutein on ovarian ischemia-reperfusion injury in rats | ||
| Author: C. Turkler, N. G. Kulhan, N. Ata, T. Kiremitli, F. Keskin Cimen, H. Suleyman | ||
| Abstract: OBJECTIVES: The aim of our study is to investigate biochemical and histopathological effects of lutein on the ovarian ischemia-reperfusion (I/R) injury in rats. BACKGROUND: Reactive oxygen species and cytokines have a very important role in the pathogenesis of I/R injury. Lutein and its derivatives may show an anti-inflammatory effect in relation to the decrease in inflammatory cytokines and increase in antioxidant enzymes. METHODS: Wistar albino female rats were randomly divided into three groups before surgery as follows: I/R group (IRG; n = 6), 1 mg/kg lutein + I/R group (LIRG; n = 6), and a healthy control group scheduled for a sham operation (SG; n = 6). The condition of ovarian ischemia was created by vascular clips. After two hours, the ovary was reperfused. Then, cyclooxygenase-1, cyclooxygenase-2, malondialdehyde and total glutathione levels were examined in ovary tissues of rats. RESULTS: As the results of our study demonstrated, in ovarian tissues of animals after I/R, there was an increase in the levels of malondialdehyde and cyclooxygenase-2, while total glutathione and cyclooxygenase-1 were decreased. At the same time, it has been observed however that these ratios are reversed in the LIRG group (p < 0.05). CONCLUSION: Lutein ameliorates the I/R-induced ovarian injury in rats by its antioxidative and anti-inflammatory activities (Fig. 2, Ref. 39). |
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| Keywords: lutein, ischemia-reperfusion, rat, ovary | ||
| Published online: 29-Nov-2018 | ||
| Year: 2018, Volume: 119, Issue: 11 | Page From: 713, Page To: 717 | |
| doi:10.4149/BLL_2018_127 |
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