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Neoplasma Vol.66, No.2, p.240-244, 2019 |
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Title: Effects of trastuzumab on the proliferation and apoptosis of ovarian cancer cells | ||
Author: J. Cong, R. Liu, J. Hou, X. Wang, H. Jiang, J. Wang | ||
Abstract: This study investigates the effects of trastuzumab on the proliferation and apoptosis of ovarian cancer cells. Epithelial ovarian cancer tissues were collected from 60 patients, benign ovarian tissues from 45 patients and normal ovarian tissues from 30 patients. Human epidermal growth factor receptor 2 (HER2) protein expression was measured by immunohistochemistry and mRNA expression by quantitative real-time polymerase chain reaction (RT-PCR). Proliferation and apoptosis of SKOV3 cells were then measured by MTS assay and flow cytometry and cleaved caspase-3 expression was detected by Western blot. Our results established that HER2 protein is expressed in tumor tissues, benign tissues and normal tissues and its positive expression rate in tumor tissues is significantly higher than in benign tissues and normal tissues (p |
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Keywords: trastuzumab, ovarian cancer, cell proliferation, apoptosis | ||
Published online: 19-Mar-2019 | ||
Year: 2019, Volume: 66, Issue: 2 | Page From: 240, Page To: 244 | |
doi:10.4149/neo_2018_180724N524 |
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