Home FOR AUTHORS Neoplasma 2019 Neoplasma Vol.66, No.2, p.240-244, 2019

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Neoplasma Vol.66, No.2, p.240-244, 2019

Title: Effects of trastuzumab on the proliferation and apoptosis of ovarian cancer cells
Author: J. Cong, R. Liu, J. Hou, X. Wang, H. Jiang, J. Wang

Abstract: This study investigates the effects of trastuzumab on the proliferation and apoptosis of ovarian cancer cells. Epithelial ovarian cancer tissues were collected from 60 patients, benign ovarian tissues from 45 patients and normal ovarian tissues from 30 patients. Human epidermal growth factor receptor 2 (HER2) protein expression was measured by immunohistochemistry and mRNA expression by quantitative real-time polymerase chain reaction (RT-PCR). Proliferation and apoptosis of SKOV3 cells were then measured by MTS assay and flow cytometry and cleaved caspase-3 expression was detected by Western blot. Our results established that HER2 protein is expressed in tumor tissues, benign tissues and normal tissues and its positive expression rate in tumor tissues is significantly higher than in benign tissues and normal tissues (p

Keywords: trastuzumab, ovarian cancer, cell proliferation, apoptosis
Published online: 19-Mar-2019
Year: 2019, Volume: 66, Issue: 2 Page From: 240, Page To: 244
doi:10.4149/neo_2018_180724N524


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