Home Bratislava Medical Journal 2018 Bratislava Medical Journal Vol.119, No.12, p.757–761, 2018

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345
 

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Bratislava Medical Journal Vol.119, No.12, p.757–761, 2018

Title: Crocin and voluntary exercise promote heart angiogenesis through Akt and ERK1/2 signalling in type 2 diabetic rats
Author: H. Dariushnejad, M. Mohammadi, V. Ghorbanzadeh

Abstract: signalling.
METHODS: Animals were divided into 4 groups as follows: diabetes (Dia), diabetic-crocin (Dia-Cro), diabetic-voluntary exercise (Dia-Exe), diabetic-crocin-voluntary exercise (Dia-Cro-Exe). Type 2 diabetes was induced by high-fat diet (4 weeks) and injection of streptozotocin (STZ) (i.p., 35 mg/kg). Animals received crocin orally (50 mg/kg), voluntary exercise was performed alone or together with crocin for 8 weeks. Akt and ERK1/2 levels were measured by ELISA and CD31 was detected by immunohistochemistry.
RESULTS: Akt and ERK1/2 levels in crocin and exercise groups were significantly higher than in diabetic group. Levels of Akt and ERK1/2 proteins and CD31 immunostaining were also significantly higher in crocin-voluntary exercise group in comparison to the other groups.
CONCLUSION: Our results revealed that treatments with crocin and voluntary exercise had synergistic effect on angiogenesis. Protective effects of these interventions are probably through the activation of Akt and ERK 1/2 signalling pathways in the heart of diabetic rats (Fig. 3, Ref. 40).

Keywords: type 2 diabetes, crocin, voluntary exercise, Akt; ERK1/2
Published online: 17-Dec-2018
Year: 2018, Volume: 119, Issue: 12 Page From: 757, Page To: 761
doi:10.4149/BLL_2018_138


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