Home Bratislava Medical Journal 2018 Bratislava Medical Journal Vol.119, No.12, p.762–769, 2018

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345
 

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Bratislava Medical Journal Vol.119, No.12, p.762–769, 2018

Title: Increased lipocalin-2 vs reduced oxytocin in relation with adiposity, atherogenicity and hematological indices in metabolic syndrome patients with and without prediabetes
Author: K. O. Tofiq, N. Bulatova, V. Kasabri, M. Suyagh, L. Halaseh, S. Alalawi

Abstract: OBJECTIVES: The neuropeptide hormone- Oxytocin (OXT) and glycoprotein Lipocalin-2 (LCN-2) are strongly associated with cardiometabolic risks of insulin resistance in metabolic syndrome (MetS) and prediabetes (preDM).
METHODS: In a cross sectional design we aimed to compare and correlate plasma levels of OXT and LCN-2 and a set of clinical parameters, adiposity indices, atherogenicity indices, and hematological indices in 29 MetS/preDM individuals and 29 non-diabetic MetS subjects  vs 30 normoglycemic lean controls. Colorimetric enzymatic assays of biomarkers were procured.
RESULTS: LCN-2 concentration (ng/mL) increased significantly in MetS/preDM  vs controls. Substantially in MetS recruits (both non-diabetic and pre-diabetics; n  =  58); OXT directly correlated with visceral adiposity index (VAI), non-HDL-C/HDL-C ratio, TC/HDL-C ratio, LDL-C/HDL-C ratio, lipid accumulation product (LAP), and atherogenicity index of plasma (AIP). Impressively, LCN-2 correlated proportionally with waist circumference (WC), red cell distribution width (RDW), neutrophils, and neutrophils to lymphocytes ratio (NLR), but inversely with lymphocytes in the 58 (non- and preDM) MetS participants.
CONCLUSIONS: These pronounced variations and correlations of OXT and LCN-2 emphasize their putative molecular roles in MetS and preDM pathophysiologies. Thus, OXT and LCN-2 can be surrogate prognostic/diagnostic tools for the MetS/preDM pharmacotherapy/prevention (Tab. 3, Fig. 1, Ref. 44).

Keywords: prediabetes, metabolic syndrome, adiposity indices, hematology indices, atherogenicity indices, oxytocin, lipocalin-2
Published online: 17-Dec-2018
Year: 2018, Volume: 119, Issue: 12 Page From: 762, Page To: 769
doi:10.4149/BLL_2018_139


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