Home Bratislava Medical Journal 2018 Bratislava Medical Journal Vol.119, No.12, p.790–792, 2018

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345
 

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Bratislava Medical Journal Vol.119, No.12, p.790–792, 2018

Title: Type II deiodinase polymorphism: A potential risk factor of type 2 diabetes mellitus
Author: S. Sotak, M. Felsoci, I. Lazurova, V. Habalova

Abstract: ype 2 diabetes mellitus (T2DM) remains one of the most challenging global epidemics of the twenty-first century. It is estimated that more than 350 million people worldwide are affected by this metabolic disorder. It has many risk factors. Several studies presume that type II iodothyronine deiodinase polymorphism Thr92Ala (DII-Thr92-Ala, rs225014) is yet another risk factor. The aim of the study was to assess the impact of this polymorphism on parameters of glycid metabolism. Our group consisted of 200 subjects (74 males and 126 females) at average age of 63.85 ± 18.98 without prediabetes, diabetes mellitus or any thyropathy. Blood tests were performed to evaluate glucose metabolism parameters as well as DII-Thr92Ala polymorphism. Our study confirmed the relationship between Ala homozygotes and glycosylated haemoglobin (HbA1c) serum levels (Tab. 2, Ref. 14).

Keywords: diabetes mellitus 2, deiodinase II, polymorphism Thr92Ala
Published online: 17-Dec-2018
Year: 2018, Volume: 119, Issue: 12 Page From: 790, Page To: 792
doi:10.4149/BLL_2018_144


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