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Endocrine Regulations 2008 Endocrine Regulations Vol.42, p.121-127, 2008
Endocrine Regulations 2008 Endocrine Regulations Vol.42, p.121-127, 2008
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Endocrine Regulations Vol.42, p.121-127, 2008 |
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| Title: BIOCHEMICAL MARKERS OF BONE REMODELING CORRELATE NEGATIVELY WITH CIRCULATING TSH IN POSTMENOPAUSAL WOMEN | ||
| Author: I. ZOFKOVA, M. HILL | ||
| Abstract: Objective. To evaluate the interrelations between circulating TSH and bone metabolism in postmenopausal women. Patients and Methods. In a total of 60 postmenopausal women serum level of several hormones (thyrotropin [TSH], free thyroxine [FT4], dehydroepiandrosterone sulfate [DHEAS], parathyroid hormone [PTH]), bone turnover markers (carboxyterminal propeptide of type I procollagen [PICP] and cross-linked telopeptide of type I collagen [ICTP]) as well as of other compounds such as IGF-I, sex hormone binding globulin (SHBG), 25-OH vitamin D3 (25-OHD3) and urinary free deoxypyridinoline (Dpd (2h)) concentrations were estimated. Bone mineral density (BMD) at the spine and BMD at the hip were measured by DXA method. Results. Sperman´s correlation showed negative association between serum TSH and urinary Dpd (pional study suggested negative association between serum TSH and markers of bone resorption in postmenopausal women. It also confirmed the well known mutual interrelations between BMD at the hip and a number of hormonal indices. Although our results did not provide any evidence on the effect of serum TSH and/or SHBG and DHEAS on bone metabolism, they showed some predictive value of these parameters to bone health. |
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| Keywords: TSH- Bone remodeling – PICP – ICTP - Bone mineral density | ||
| Year: 2008, Volume: 42, Issue: 4 | Page From: 121, Page To: 127 | |
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