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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

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neo_2018_180613N393

Title: Local delivery of temozolomide via a biologically inert carrier (Temodex) prolongs survival of glioma patients irrespectively of the MGMT methylation status
Author: I. Karlsson, D. Veevnik, A. Fedulov, N. Yurkshtovich, T. Yurkshtovich, G. Pejler, I. Lokot

Abstract: Glioma is the most common brain malignancy. Standard first-line therapy for glioma includes surgery, radiotherapy and systemic administration of temozolomide. However, temozolomide does not reach the brain in sufficient doses when administered orally and has poor efficiency in more than half of the patients. Strategies to improve the treatment of glial malignancies are therefore needed. We have recently developed a system (Temodex) for local administration of temozolomide by encapsulating the drug in a biologically inert matrix. Here, we assessed the effect of Temodex in combination with standard therapy in a small-scale clinical study. Since the efficacy of temozolomide therapy is known to depend on the methylation status of the O6-methylguanine-DNA methyltransferase gene (MGMT) promoter, we also analysed whether the effect of Temodex was influenced by the methylation status of MGMT. Our data show that the combination of standard therapy and Temodex was more efficient than standard therapy alone, promoting the overall patient survival by up to 33 weeks. Moreover, the efficacy of Temodex was not dependent on the methylation status of MGMT. Local Temodex administration in combination with standard therapy thereby emerges as a novel therapeutic option, with applicability that is independent on the methylation status of the MGMT promoter.

Keywords: glioma, Temodex, temozolomide, MGTM, methylation
Published online: 19-Dec-2018
Year: , Volume: , Issue: Page From: , Page To:
doi:10.4149/neo_2018_180613N393


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