Home Bratislava Medical Journal 2019 Bratislava Medical Journal Vol.120, No.2, p.124–130, 2019

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345
 

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Bratislava Medical Journal Vol.120, No.2, p.124–130, 2019

Title: Role of Gal-3 and H-FABP in the early diagnosis of acute coronary syndrome
Author: E. Atay, M. Guzel, R. Amanvermez, M. T. Demir, A. K. Erenler, E. Ozgen, M. Yucel

Abstract: OBJECTIVES: We aimed to compare the plasma levels of biomarkers such as: serum Gal-3, H-FABP, cTnI, and CK-MB in patients, who were admitted to the emergency room with chest pain, and to determine whether these biomarkers have early diagnostic value of acute coronary syndrome (ACS).
METHODS: The study was performed in 60 patients aged ≥ 18 years, who were admitted to emergency room. These patients were divided into 3 groups: patients with STEMI (group I, n = 20), patients with NSTEMI (group II, n = 20), and patients with USAP (group III, n = 20). Serum Gal-3, H-FABP, cTnI, and CK-MB levels were measured at admission, and at the 2nd and 4th hours.
RESULTS: There were statistically significant differences between the groups in terms of Gal-3 levels at admission, and the 2nd and 4th hours (p = 0.007, p = 0.002, and p = 0.001, respectively). There were statistically significant differences between the groups in terms of H-FABP levels at admission, and the 2nd and 4th hours (p = 0.001, p = 0.003, and p = 0.003, respectively).There were statistically significant differences between the groups in terms of cTnI levels at admission, and the 2nd and 4th hours (p < 0.001, p < 0.001, and p < 0.001, respectively).
CONCLUSIONS: According to the results of the study, cTnI, H-FABP, and Gal-3 are useful parameters that can be used in the early diagnosis of ACS (Tab. 4, Ref. 36).

Keywords: acute coronary syndromes, emergency room, galectin-3, heart-type fatty acid-binding protein
Published online: 17-Feb-2019
Year: 2019, Volume: 120, Issue: 2 Page From: 124, Page To: 130
doi:10.4149/BLL_2019_020


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