Home Bratislava Medical Journal 2019 Bratislava Medical Journal Vol.120, No.2, p.131–138, 2019

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345
 

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Bratislava Medical Journal Vol.120, No.2, p.131–138, 2019

Title: The role of selenium in bevacizumab induced cardiotoxicity
Author: C. R. Oncel, I. S. Ovey

Abstract: OBJECTIVE: We investigated the role of selenium in bevacizumab induced cardiotoxicity and involvement of transient receptor potential vanilloid 1 (TRPV1) channels in cardiomyocytes.
MATERIALS AND METHODS: All cells (Human cardiomyocyte cell line) were cultured at 37 °C. We divided the cells into seven groups as control, bevacizumab, bevacizumab + capsazepin, bevacizumab + selenium, bevacizumab + selenium + capsazepin, selenium and selenium + capsazepin groups. Cells in the groups were stimulated with capsaicin and inhibited with capsazepin in related experiments for activation and inactivation of TRPV1 channels, respectively.
RESULTS: Cytosolic calcium, apoptosis and intracellular ROS production levels were lower in bevacizumab + selenium group than in the bevacizumab group of cardiomyocytes (p ˂ 0.001). Also, values were markedly lower in the bevacizumab + selenium + capsazepine group when compared to the bevacizumab + selenium group (p ˂ 0.001).
CONCLUSION: We found that cytosolic calcium, apoptosis, intracellular ROS production levels were increased in bevacizumab induced cardiotoxicity and selenium treatment could have beneficial effects on these parameters (Fig. 5, Ref. 51).

Keywords: apoptosis, bevacizumab, cardiomyocyte, transient receptor potential vanilloid 1, selenium
Published online: 17-Feb-2019
Year: 2019, Volume: 120, Issue: 2 Page From: 131, Page To: 138
doi:10.4149/BLL_2019_021


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