Home HOME Neoplasma 2019 Neoplasma Vol.66, No.3, p.336-342, 2019

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

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Neoplasma Vol.66, No.3, p.336-342, 2019

Title: FBLN3 inhibits the invasion and metastasis of colorectal cancer through the AKT/mTOR pathway
Author: H. Y. Mao, S. P. Liu, G. M. Kong, Y. Xu, Y. C. Xu, G. Z. Sun, Z. Wang, F. Han, J. D. Tong, P. Bo

Abstract: Fibulin-3 (FBLN3) levels vary among different types of cancers. We found that fibulin-3 was downregulated in colorectal cancer (CRC) cells, particularly in the SW480 cell line. However, transfecting SW480 cells with a lentivirus overexpressing fibulin-3 RNA inhibited proliferation, induced G1/S arrest, and promoted apoptosis. Fibulin-3 overexpression also suppressed CRC invasion and metastasis. These effects were regulated through the AKT/mTOR signaling pathway.

Keywords: fibulin-3, invasion, metastasis, colorectal cancer, AKT/mTOR pathway
Published online: 28-May-2019
Year: 2019, Volume: 66, Issue: 3 Page From: 336, Page To: 342

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