Home HOME Neoplasma 2019 Neoplasma Vol.66, No.3, p.377-385, 2019

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

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Neoplasma Vol.66, No.3, p.377-385, 2019

Title: Ambra1 inhibits paclitaxel-induced apoptosis in breast cancer cells by modulating the Bim/mitochondrial pathway
Author: W.-L. Sun, L. Wang, J. Luo, H.-W. Zhu, Z.-W. Cai

Abstract: Cancer cells often evade apoptosis induced by anti-cancer drugs, thereby reducing their efficacy. Autophagy/Beclin 1 regulator 1 (Ambra1) is a crucial pro-autophagic protein. It also plays an important role in the execution of apoptosis. However, the mechanism by which Ambra1 regulates apoptosis has not been fully clarified. Moreover, whether Ambra1 participates in the regulation of paclitaxel-induced apoptosis in breast cancer cells is not clear. Herein, we show that Ambra1 inhibits paclitaxel-induced apoptosis in breast cancer cells. Moreover, Bim and mitochondria are key effectors of Ambra1 in this process. Thus, Ambra1 is a protein that makes breast cancer cells resistant to apoptosis by modulating the Bim/mitochondrial pathway and may therefore be a potential target for the breast cancer treatment.

Keywords: Ambra1, Bim, apoptosis, paclitaxel, breast cancer
Published online: 28-May-2019
Year: 2019, Volume: 66, Issue: 3 Page From: 377, Page To: 385
doi:10.4149/neo_2018_180710N467


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