Home HOME Neoplasma 2019 Neoplasma Vol.66, No.3, p.405-419, 2019

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ISSN 1338-4317 (online)

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Neoplasma Vol.66, No.3, p.405-419, 2019

Title: Zonula occludens-1 associated nucleic acid binding protein plays an invasion-promoting role in bladder cancer
Author: X. Xu, K. You, B. Wu

Abstract: Cancer cell invasion is an important characteristic of malignant tumors. Cancer cells overcome the constraints of tight junctions (TJ) to invade other tissues, but less is known about the regulating role of tight junctions in bladder cancer (BC) invasion. In order to identify the invasion-regulating function of tight junction component, we investigated the oncogenic features of zonula occludens-1 associated nucleic acid binding protein (ZONAB), a TJ protein that is usually highly expressed in solid cancers. Expression of ZONAB was found to be up-regulated in human BC cell lines detected by real-time PCR and Western blotting. ZONAB expression was significantly up-regulated in BC cell lines and negatively regulated E-cadherin expression. Overexpression of ZONAB by stable transduction in human BC cell lines promoted invasion detected by transwell invasion assay. Conversely, stable suppression of ZONAB expression by RNA interference (RNAi) in BC cells attenuated invasion. A similar role of ZONAB in promoting invasion and EMT was observed in xenografts. In summary, ZONAB is up-regulated in BC cell lines and promotes invasion, demonstrating the important role it plays in tumorigenesis and cancer progression.

Keywords: zonula occludens-1 associated nucleic acid binding protein, bladder cancer, tight junction protein, invasion, metastasis
Published online: 28-May-2019
Year: 2019, Volume: 66, Issue: 3 Page From: 405, Page To: 419
doi:10.4149/neo_2018_180725N530


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