Home Neoplasma Ahead of print Neoplasma Vol.66, No.4, p.516-523, 2019

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ISSN 0028-2685
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Neoplasma Vol.66, No.4, p.516-523, 2019

Title: Exosomal miRNA423-5p mediated oncogene activity in papillary thyroid carcinoma: a potential diagnostic and biological target for cancer therapy
Author: W. Ye, X. Deng, Y. Fan
Abstract: Exosomes are considered important “messengers” between cells and their cargo, and some of the miRNAs composing their cargo may be involved in oncogenic activity. Exosomal miRNA423-5p (Ex-miRNA423-5p) is upregulated in gastric cancer and associated with its poor prognosis. However, the role of exosome-derived miRNAs in papillary thyroid cancer (PTC) is still unclear and needs further study. In our work, we found that the level of Ex-miRNA423-5p was significantly increased in the serum of PTC patients compared with the serum of normal healthy people, and in vitro, we demonstrated that miRNA423-5p entered thyroid cancer cells through exosomes from thyroid cancer cell supernatant. Functional experiments demonstrated that overexpression of miRNA423-5p mimics in exosomes increased PTC cell migration and invasion, while the silencing of miRNA423-5p in TPC-1 cell exosomes inhibited PTC cell migration and invasion in vitro. These findings indicate that Ex-miRNA423-5p might serve as a potential tumor marker; thus, silencing miRNA423-5p in exosomes might represent a potential approach against PTC.
Keywords: exosome, miRNA423-5p, papillary thyroid carcinoma, migration, invasion
Published online: 29-Jul-2019
Year: 2019, Volume: 66, Issue: 4 Page From: 516, Page To: 523
doi:10.4149/neo_2018_180824N643


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