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Bratislava Medical Journal 2019 Bratislava Medical Journal Vol.120, No.3, p.212–217, 2019
Bratislava Medical Journal 2019 Bratislava Medical Journal Vol.120, No.3, p.212–217, 2019
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Bratislava Medical Journal Vol.120, No.3, p.212–217, 2019 |
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| Title: Anti-tumor effects of lidocaine on human gastric cancer cells in vitro | ||
| Author: L. Ye, Y. Zhang, Y. J. Chen, Q. Liu | ||
| Abstract: Currently, there exists an urgent need to investigate the anti-cancer effects of lidocaine on gastric cancer cells. The purpose of the present study was to evaluate the anti-tumor effects and the underlying mechanisms of lidocaine in gastric cancer cells. Our results indicated that lidocaine significantly suppressed proliferation, migration and invasion and induced apoptosis in a dose-dependently manner in human gastric cancer cells. In addition, our data shown that the expression of Bcl-2 was decreased and the level of Bax was increased by lidocaine treatment. Furthermore, we found that lidocaine altered the protein expression of the MAPK pathway. p-p38 was also increased simultaneously, while the level of p38 was not changed. In summary, lidocaine has a prominent anti-tumor activity on gastric cancer cells and is a promising therapeutic agent for the treatment of gastric cancer (Fig. 4, Ref. 32). |
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| Keywords: lidocaine, gastric cancer cells, anti-tumor effect, MAPK pathway | ||
| Published online: 19-Mar-2019 | ||
| Year: 2019, Volume: 120, Issue: 3 | Page From: 212, Page To: 217 | |
| doi:10.4149/BLL_2019_036 |
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