Home General Physiology and Biophysics 2019 General Physiology and Biophysics Vol.38, No.2, p.183–186, 2019

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Quarterly, 80 pp. per issue
Founded: 1982
ISSN  1338-4325 (online)

Published in English

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General Physiology and Biophysics Vol.38, No.2, p.183–186, 2019

Title: The diamide insecticide chlorantraniliprole increases the single-channel current activity of the mammalian skeletal muscle ryanodine receptor
Author: Z. É. Magyar, G. Diszházi, J. Péli-Szabó, P. Szentesi, C. Collet, L. Csernoch, P. Nánási, J. Almássy

Abstract: Very recently, the diamide insecticide chlorantraniliprole was shown to induce Ca2+-release from sarcoplasmic reticulum (SR) vesicles isolated from mammalian skeletal muscle through the activation of the SR Ca2+ channel ryanodine receptor. As this result raises severe concerns about the safety of this chemical, we aimed to learn more about its action. To this end, single-channel analysis was performed, which showed that chlorantraniliprole induced high-activity bursts of channel opening that accounts for the Ca2+-releasing action described before.

Keywords: Ryanodine receptor, Diamide, Insecticide, Chlorantraniliprole
Published online: 25-Mar-2019
Year: 2019, Volume: 38, Issue: 2 Page From: 183, Page To: 186

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