Home General Physiology and Biophysics 2019 General Physiology and Biophysics Vol.38, No.2, p.187–190, 2019

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Quarterly, 80 pp. per issue
Founded: 1982
ISSN  1338-4325 (online)

Published in English

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General Physiology and Biophysics Vol.38, No.2, p.187–190, 2019

Title: Chronic predator scent stress alters serotonin and dopamine levels in the rat thalamus and hypothalamus, respectively
Author: E. Dremencov, M. Lapshin, M. Komelkova, A. Alliluev, O. Tseilikman, M. Karpenko, N. Pestereva, E. Manukhina, H. F. Downey, V. Tseilikman

Abstract: The aim of this study was to investigate the effect of chronic predator scent stress (PSS) on monoamine levels in rat thalamus and hypothalamus. Rats were exposed to the PSS (sand containing cat urine) for ten minutes daily for ten days. Control animals were exposed to the sand containing clean water. Fifteen days later, rats’ behavior and thalamic and hypothalamic levels of monoamines were analyzed. PSS rats had elevated anxiety, increased thalamic serotonin and decreased hypothalamic dopamine concentrations. This decrease in hypothalamic dopamine may explain, at least in part, lowered corticosterone levels observed in PSS animals in our previous studies.

Keywords: Post-traumatic stress disorder, Predator scent stress, Serotonin, Norepinephrine, Dopamine, HPLC
Published online: 25-Mar-2019
Year: 2019, Volume: 38, Issue: 2 Page From: 187, Page To: 190

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