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Bratislava Medical Journal 2019 Bratislava Medical Journal Vol.120, No.4, p.291–294, 2019
Bratislava Medical Journal 2019 Bratislava Medical Journal Vol.120, No.4, p.291–294, 2019
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Bratislava Medical Journal Vol.120, No.4, p.291–294, 2019 |
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| Title: The effect of long term testosterone replacement therapy on bone mineral density | ||
| Author: J. Fillo, M. Levcikova, J. Luha, D. Ondrus | ||
| Abstract: OBJECTIVE: Long-term results of testosterone replacement therapy (TRT) on bone mineral density (BMD) in literature are still missing. MATERIALS AND METHODS: Totally, 45 males with testosterone deficiency syndrome (TDS) underwent TRT. The mean age was 57.84 years and the follow-up period was 94.62 months. Males were treated with three-month intramuscular injections of 1000 mg testosterone undecanoate. BMD was check at beginning of treatment, after two years and after 5 years. For a statistic evaluation, nonparametric Wilcoxon test was used. RESULTS: Mean BMD of lumbar spine was 1.067 at beginning, 1.122 after two years and 1.667 and after 5 years. The results after two and also 5 years showed a significant improvement (p < 0.001). CONCLUSION: Authors proved a positive effect of long-term TRT on BMD of the lumbar spine. Densitometry of the whole hip showed also an improvement, but only after 5 years. Densitometry of the femoral neck was relatively stable. Important is that despite the fact that males became older, BMD values of the lumbar spine were improved (Fig. 6, Ref. 18). |
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| Keywords: Testosterone deficiency syndrome, testosterone replacement therapy, densitometry, bone mineral density | ||
| Published online: 26-Apr-2019 | ||
| Year: 2019, Volume: 120, Issue: 4 | Page From: 291, Page To: 294 | |
| doi:10.4149/BLL_2019_039 |
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