Home HOME Neoplasma 2019 Neoplasma Vol.66, No.4, p.637-640, 2019

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

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Neoplasma Vol.66, No.4, p.637-640, 2019

Title: The value of detecting pepsinogen and gastrin-17 levels in serum for pre-cancerous lesion screening in gastric cancer
Author: G. Yu, G. X. Wang, H. G. Wang, F. F. Mo, B. B. Tang

Abstract: The aim of the study was to estimate the value of detecting pepsinogen (PG) I, PGII and gastrin-17 (G-17) levels in serum for chronic atrophic gastritis (CAG) screening and to determine the clinical applicability of combined measurement of serum G-17, pepsinogens (PGI, PGII) and PGI/PGII ratio (PGR) as a screening test for CAG. The PGI, PGII and G-17 levels were detected by ELISA in 68 patients with CAG and 86 healthy volunteers who underwent gastroscopy for gastroduodenal diseases at Taizhou Municipal Hospital between January 2016 and December 2016. Concentrations of all measured serum markers were lower in patients with CAG in comparison to healthy volunteers and achieved statistical significance (pcan raise the diagnostic accuracy of CAG in some respects. However, further research including a larger sample size is necessary in order to accurately determine the sensitivity and specificity of combined detection of serum indicators.

Keywords: pepsinogen, gastrin-17, chronic atrophic gastritis, precancerous lesions, gastric cancer
Published online: 29-Jul-2019
Year: 2019, Volume: 66, Issue: 4 Page From: 637, Page To: 640

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