Neoplasma Vol.66, No.4, p.637-640, 2019
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| Title: The value of detecting pepsinogen and gastrin-17 levels in serum for pre-cancerous lesion screening in gastric cancer |
| Author: G. Yu, G. X. Wang, H. G. Wang, F. F. Mo, B. B. Tang |
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Abstract: The aim of the study was to estimate the value of detecting pepsinogen (PG) I, PGII and gastrin-17 (G-17) levels in serum for chronic atrophic gastritis (CAG) screening and to determine the clinical applicability of combined measurement of serum G-17, pepsinogens (PGI, PGII) and PGI/PGII ratio (PGR) as a screening test for CAG. The PGI, PGII and G-17 levels were detected by ELISA in 68 patients with CAG and 86 healthy volunteers who underwent gastroscopy for gastroduodenal diseases at Taizhou Municipal Hospital between January 2016 and December 2016. Concentrations of all measured serum markers were lower in patients with CAG in comparison to healthy volunteers and achieved statistical significance (pcan raise the diagnostic accuracy of CAG in some respects. However, further research including a larger sample size is necessary in order to accurately determine the sensitivity and specificity of combined detection of serum indicators.
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| Keywords: pepsinogen, gastrin-17, chronic atrophic gastritis, precancerous lesions, gastric cancer |
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Published online: 29-Jul-2019
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| Year: 2019, Volume: 66, Issue: 4 |
Page From: 637, Page To: 640 |
doi:10.4149/neo_2018_180825N647
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